DESIGN AND EVALUATION OF SINTERED MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE

In the present work, sustained release (SR) sintered matrix tablets of Verapamil hydrochloride were prepared by trituration method using 4% and 8% HPMC K4M and HPMC K15M and then sintered. The prepared tablets were transferred to the sintering chamber (dessicator filled with acetone in the bottom and equilibrated for 24 hours with vapour) and exposed to different sintering time like 3 hours and 6 hours. The release characteristics study was carried out in USP XXI model.