Topical NSAIDs and Upper Gastrointestinal Bleeding and Perforation

Introduction: The relationship between topically applied non-steroidal anti-inflammatory drugs (TNSAIDs) and gastroduodenal complications is uncertain. The aim of this study was to investigate the hypothesis that TNSAIDs are associated with upper gastrointestinal bleeding and perforation (UGIBP) using a record-linkage database containing all hospital event and dispensing data between 1989 – 1992 in a population of approximately 400 000 people.