In two parallel pragmatic equivalence trials, leukotriene receptor antagonists as initial therapy for asthma compared with inhaled corticosteroids and as add on therapy to ICS compared with adding long-acting β agonists provided equivalent short-term asthma quality of life but were associated with more medication switches.

2012 
Commentary on: D Price, SD Musgrave, L Shepstone, et al.. Leukotriene antagonists as first-line or add-on asthma-controller therapy. N Engl J Med2011;364:1695–707.
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