Vancomycin Ototoxicity and Nephrotoxicity A Review

Vancomycin has been in clinical use as a potent antistaphylococcal antibiotic for over 30 years. Most reports of ototoxicity and nephrotoxicity have been associated with early, relatively impure, formulations of vancomycin. This paper reviews the literature concerning vancomycin otoxocity and nephrotoxicity and the evidence for their correlation with the therapeutic serum concentration range.