Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

// Dongming Chen 1, * , Jun Dong 1, * , Ying Huang 2, * , Feng Gao 1 , Xiaopeng Yang 1 , Xianglun Gong 1 , Xiaochen Lv 3 , Chenghao Chu 4 , Yonggang Wu 1 and Yong Zheng 5 1 Neurosurgery Department, People’s Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830001, Xinjiang, China 2 Respiratory Department, People’s Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830001, Xinjiang, China 3 Nursing College of Xinjiang Medical University, Urumqi 830001, Xinjiang, China 4 Tumor Hospital of Xinjiang Medical University, Urumqi 830001, Xinjiang, China 5 Neurosurgery Department, The Eighth People’s Hospital of Shenzhen, Shenzhen 518101, Guangdong, China * These authors have contributed equally to this work Correspondence to: Yong Zheng, email: xjzy3682@126.com Yonggang Wu, email: wyg931543@163.com Keywords: glioma, meningioma, MTHFR, MTRR, SNP: meta-analysis Received: November 15, 2016     Accepted: June 01, 2017     Published: July 04, 2017 ABSTRACT Polymorphic variants of genes involved in folate metabolism are implicated in the susceptibility to meningioma and glioma, but the results from published articles are controversial and inconclusive. Therefore, we performed this meta-analysis including all studies available to evaluate the relationship between folate metabolism genetic polymorphisms and the susceptibility to meningioma and glioma in adults. We searched the literature in PubMed, EMBASE and Cochrane Central Library for relevant articles published up to August 2016. The odds ratios (ORs) and the corresponding 95% confidence intervals (95%Cls) were used to evaluate the associations of two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) with the risk of meningioma and glioma in adults. We found significant association of MTHFR A1298C (rs1801131) variant genotypes with increased incidence of meningioma and glioma in this study population (CA vs. AA: OR=1.22, P<0.001; CA+CC vs. AA: OR=1.18, P=0.002). Moreover, we found that MTRR A66G (rs1801394) variant genotypes was associated with increased risk of meningioma and glioma (G vs. A: OR=1.11, P=0.020; GG vs. AA+AG: OR=1.17, P=0.043; GG vs. AA: OR=1.22, P=0.023). In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.