Duration of sleep and risk of colorectal adenoma.

e14023 Background: Very few studies have investigated the associations of duration and quality of sleep with risk of colorectal neoplasia. Methods: In an ongoing screening colonoscopy-based study of colorectal adenomas, the Pittsburg Sleep Quality Index (PSQI) was administered to 1,240 study participants prior to their screening colonoscopy. Three hundred and thirty eight (27.3%) of the participants were diagnosed with incident colorectal adenomas. Results: Although there was no appreciable difference in the overall sleep quality as measured by the PSQI score between cases and adenoma-free controls (5.32 vs. 5.11; p = 0.37), we found a statistically significant association of colorectal adenoma with the PSQI component 3, which corresponds to sleep duration (p = 0.018). Cases were more likely to average less than 6 hours of sleep per night (28.9% vs. 22.1% in controls, univariate p = 0.013). In multivariate regression analysis adjusted for age, gender, race, smoking, income, family history of colorectal ca...