Function-Inspired Design of Molecular Hydrogels: Paradigm-Shifting Biomaterials for Biomedical Applications

Molecular hydrogels represent a fascinating area of research that has its roots in drug delivery. However, now molecular hydrogels play an intrinsic role in a multitude of applications in various fields of biomedical research such as bioengineering, immunotherapy, tissue adhesives and sealants, cell growth matrices, and stimuli-responsive materials. The design of new biomaterials that can release cargo depending on multiple stimuli and their capacity to hold vast amounts of cargo has significantly expanded their use. However, their clinical translation is still dependent on their intrinsic design and is governed by multiple factors such as easy clearance, lack of immune response, and breakdown into nontoxic products. This chapter describes a few accounts of a new class of molecular hydrogels with their potential applications through preclinical models.