Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein

Shenlin Wang,Rachel A. Munro,Lichi Shi,Izuru Kawamura,Takashi Okitsu,Akimori Wada,So Young Kim,Kwang-Hwan Jung,Leonid S. Brown,Vladimir Ladizhansky

Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein

2013

Shenlin Wang
Rachel A. Munro
Lichi Shi
Izuru Kawamura
Takashi Okitsu
Akimori Wada
So Young Kim
Kwang-Hwan Jung
Leonid S. Brown
Vladimir Ladizhansky

A strategy, based on solid-state NMR spectroscopy, for determining the structure of an oligomeric, seven-helix membrane protein (Anabaena sensory rhodopsin) in a lipid environment is described.

Keywords:

Solid-state nuclear magnetic resonance
Spectroscopy
Nuclear magnetic resonance spectroscopy
Rhodopsin
Integral membrane protein
Membrane protein
Membrane fluidity
Peripheral membrane protein
Molecular biology
Biology
Biochemistry
Protein structure
Biophysics

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