Fit-for-purpose biomarker LC–MS/MS qualification for the quantitation of very long chain fatty acids in human cerebrospinal fluid

John Williams,Kan Zhu,Eric Crampon,André Iffland

Fit-for-purpose biomarker LC–MS/MS qualification for the quantitation of very long chain fatty acids in human cerebrospinal fluid

2020

John Williams
Kan Zhu
Eric Crampon
André Iffland

Aim: Very long chain fatty acids (VLCFAs) have been identified as biomarkers for several peroxisomal disorders necessitating the need for reliable biomarker assays in particular C20, C22, C24, C26 ...

Keywords:

Chromatography
Liquid chromatography–mass spectrometry
Peroxisomal disorder
Cerebrospinal fluid
Chemistry
Biomarker (medicine)
Derivatization
nonspecific binding
lc ms ms
very long chain

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