Метаболизм железа как патогенетическое звено развития инфекционных осложнений при муковисцидозе

Information on iron metabolism has been significantly supplemented and changed in recent decades. The reviewprovides data on the main proteins involved in iron metabolism in humans. The mechanisms of iron acquisition in bacteriafrom the macroorganism and their importance in the development of infectious and inflammatory process in patientswith cystic fibrosis are described. Data on the significance of Burkholderia cepacia complex and Pseudomonasaeruginosa siderophores in the processes of binding and transport of iron to bacterial cells are presented. The result ofcomplex interactions of bacteria and macroorganism in cystic fibrosis can be the development of severe exacerbations,including “cepation-syndrome”, which, taking into account the above data, should be considered not only as directdamage to the lung tissue by bacteria, but also as a factor in the formation of a “vicious circle”: viscous sputum leads toinfection of the lower respiratory tract with microorganisms that need iron and release it from the tissues, which canstimulate not only lung damage, but also lead to the growth of virulence of bacteria.