Effect of low dose of Bupivacaine(BUP) combined with morphine on Epidural labor analgesia

Objective: To observe the effect of morphine and low dose of bupivacaine for epidural labor analgesia on delivery and neonates, and the side-effect on puerperal. Methods:this experiment is prospective, random and double-blind. 120 expectant mothers were randomly divided into two groups: after epidural catheter placement, 0.1%BUP+2μg /ml Fentanyl were given(BF group); and other group 0.0625% BUP + 2μg /ml Fentanyl+ 2mg morphine(BFMgroup). All the drugs were diluted to 15 ml, in BFM morphine was given one time only. Results: Total dosage of BUP in BFM group is lower than that of BF group(P = 0.0001), and the delivery time is remarkably shorter than that of BF group. Satisfaction degree after first dosage in BF group is very high(P = 0.0001), and the visual scores after15 min, 30 min and 45 min are much lower(P = 0.0001, P = 0.001, and P = 0.005). satisfaction rate of Postpartum analgesia of the two groups shows no statistical difference. 6 cases of nausea or vomiting were recorded in BFM group.Conclusion: epidural labor analgesia consisting of low dose of local anesthesia and 2mg morphine can achieve satisfactory painless labor, which causes no unfavorable effects on mothers or infants. This scheme can enhance expectant mothers' satisfaction without addition of local analgesia drug and shorten the second stage of labor.