Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis.

Bo Xi,Fumihiko Takeuchi,Aline Meirhaeghe,Norihiro Kato,John Chambers,Andrew P. Morris,Yoon Shin Cho,Weihua Zhang,Karen L. Mohlke,Jaspal S. Kooner,Xiao-Ou Shu,Hongwei Pan,E. Shyong Tai,Haiyan Pan,Jer-Yuarn Wu,Donghao Zhou,Giriraj R. Chandak

Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis.

2014

Bo Xi
Fumihiko Takeuchi
Aline Meirhaeghe
Norihiro Kato
John Chambers
Andrew P. Morris
Yoon Shin Cho
Weihua Zhang
Karen L. Mohlke
Jaspal S. Kooner
Xiao-Ou Shu
Hongwei Pan
E. Shyong Tai
Haiyan Pan
Jer-Yuarn Wu
Donghao Zhou
Giriraj R. Chandak

This meta-analysis indicates that several BMI-associated variants are significantly associated with T2D risk. Some variants increase the T2D risk independent of obesity, while others mediate this risk through obesity.

Keywords:

Obesity
Case-control study
Locus (genetics)
Diabetes mellitus
Body mass index
Type 2 diabetes
Genome-wide association study
Medicine
Genetics
Alpha-Ketoglutarate-Dependent Dioxygenase FTO

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