GLU4-may increase insulin sensitivity in type 2 diabetic rats

Objective To investigate effect of berberine on fasting glucose , fasting serum insulin, islet morphology, and ex-pression of glucose transporter 4 （GLU-4） of islet in type 2 diabetes mellitus （T2DM） rats.The present study aimed to evaluate the ually, especially for high-dose group （ P〈0.01）.⑷Compared with normal group , INS of diabetic control group was significantly de-creased （ P 〈0.05）, INS of low-dose, middle-dose, and high-dose groups were all increased gradually , especially for high-dose group （ P 〈0.01 ） .Conclusions Berberine has the effects of antidiabetes via ameliorate insulin sensitivity , and promotes GLUT-4 protein expression . Key words: Glucose transporter type 4 ;  Diabetes mellitus, type 2 ;  Insulin;  Rats, Sprague-Dawley