GASTRO-RETENTIVE FLOATING DRUG DELIVERY SYSTEM- AN APPROACH IN GASTRO- RETENTIVE DRUG DELIVERY Review Article

Oral route is considered most natural, uncomplicated, convenient and safe due to its ease of administration, patient acceptance, and cost-effective manufacturing process. In order to overcome the drawbacks of conventional drug delivery systems, several technical advancements have led to the development of controlled drug delivery system that could revolutionize method of medication and provide a number of therapeutic benefits. One of the most widely gastro retentive drug delivery system. Several approaches are currently being used to prolong the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, high-density systems, and other delayed gastric emptying devices. Floating dosage forms are emerging as a promising dosage forms. Floating dosage form can be prepared as tablets, capsules by adding suitable ingredients as well as by adding gas generating agent. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention.