Serum vitamin E levels negatively correlate with severity of age-related macular degeneration.

Abstract Age-related macular degeneration (AMD) pathogenesis has been related to UV radiation and other factors that may promote increased oxidative damage to the retina. Patients with different AMD grading ( n =25) were compared with an age-matched group of AMD-free subjects ( n =15), both groups older than 60 years. A modification of the AMD grading system is proposed that allows patient grading and not single eye grading. AMD patients showed statistically significant lower serum levels of vitamin E and Zn than AMD-free subjects. Moreover, a negative correlation (Spearman's correlation coefficient r =−0.815, P