The Human Ion Channel TRPM2 Modulates Neuroblastoma Cell Survival and Mitochondrial Function through Pyk2, CREB, and MCU Activation

Iwona Hirschler-Laszkiewicz,Shu-jen Chen,Lei Bao,JuFang Wang,Xue-Qian Zhang,Santhanam Shanmughapriya,Kerry Keefer,Muniswamy Madesh,Joseph Y. Cheung,Barbara A. Miller

The Human Ion Channel TRPM2 Modulates Neuroblastoma Cell Survival and Mitochondrial Function through Pyk2, CREB, and MCU Activation

2018

Iwona Hirschler-Laszkiewicz
Shu-jen Chen
Lei Bao
JuFang Wang
Xue-Qian Zhang
Santhanam Shanmughapriya
Kerry Keefer
Muniswamy Madesh
Joseph Y. Cheung
Barbara A. Miller

Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an essential function in cell survival and is highly expressed in many cancers. Inhibition of TRPM2 in neuroblastoma b...

Keywords:

Transient receptor potential channel
Proto-oncogene tyrosine-protein kinase Src
CREB
Neuroblastoma
Molecular biology
Cell biology
TRPM2
Cell
Ion channel
Subfamily
Biology
Mitochondrion

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