Intraoperative Frozen Section in "Suspicious for Papillary Thyroid Carcinoma" after Adoption of the Bethesda System.

ObjectiveTo evaluate the accuracy and utility of intraoperative frozen section examination (iFSE) in patients with a preoperative fine-needle aspiration (FNA) cytology of “suspicious for malignancy” (SFM)–Bethesda V, after the adoption of the Bethesda System for Reporting Thyroid Cytopathology.Study DesignCase series with chart review.SettingTertiary medical center.Subjects and MethodsAll patients with SFM–Bethesda V who underwent thyroid surgery with iFSE between 2010 and 2015 were included. In cases where the iFSE was reported to be malignant, a total thyroidectomy was performed; otherwise, thyroid lobectomy (hemithyroidectomy) was performed.ResultsThe current series included 47 patients diagnosed preoperatively with FNA cytology of SFM–Bethesda V. The malignancy rate was 74.5% (35 of 47). Twenty-four patients with nonmalignant iFSE results underwent lobectomy during their initial surgery: 12 were subsequently found with benign final histology and did not undergo completion thyroidectomy; the other 12 p...