Atypical language in lesional and nonlesional complex partial epilepsy
2007
Objective: We investigated the relationship between partial epilepsy, MRI findings, and atypical language representation. Methods: A total of 102 patients (4 to 55 years) with left hemisphere epileptogenic zones were evaluated using three fMRI language tasks obtained at 1.5 or 3T with EPI BOLD techniques: verbal fluency, reading comprehension, and auditory comprehension. fMRI maps were visually interpreted at a standard threshold and rated as left or atypical language. Results: Atypical language dominance occurred in 30 patients (29%) and varied with MRI type ( p 2 = 24.09, p p p p > 0.40). Patients with atypical language had lower verbal abilities (F = 6.96, p = 0.01) and a trend toward lower nonverbal abilities (F = 3.58, p = 0.06). There were no differences in rates of atypical language across time, age groups, or MRI scanner. Conclusion: Early seizure onset and atypical handedness, as well as the location and nature of pathologic substrate, are important factors in language reorganization. GLOSSARY: FOV = field of view; MTS = mesial temporal sclerosis; RRN = read response naming; TE = echo time; TR = repetition time; WAIS = Wechsler Adult Intelligence Scale; WISC = Wechsler Intelligence Scale for Children.
Keywords:
- Audiology
- Epilepsy
- Developmental psychology
- Physical therapy
- Verbal fluency test
- Wechsler Intelligence Scale for Children
- Lateralization of brain function
- Comprehension
- Chirality (physics)
- Wechsler Adult Intelligence Scale
- Reading comprehension
- Psychology
- Age of onset
- Magnetic resonance imaging
- Intelligence quotient
- Nonverbal communication
- Medicine
- Correction
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