Molecular requirements of the active sites of the cholinergic receptors. XIII - Stereospecific synthesis of 3c-methyl-2t-hydroxy-lr-dimethyl-aminomethylcyclopentane methiodide and its dehydroderivative.

: A stereospecific synthesis of 3c-methyl-2t-hydroxy-1r-dimethylaminomethylcyclopentane methiodide (III), which allows better yields, avoiding time-consuming column chromatography and the synthesis of its dehydroderivative (VIII) are described. This last compound, like isomer (VII) (2), shows a good cholinergic activity which, compared with that of the corresponding hydroxycompounds, further supports the dualistic hypothesis of Triggle (8) on the active sites of cholinergic receptors.