Assessment of Liver Functions among Sudanese Leukemic Patients in Khartoum State

Background: Leukaemia is a malignant disorder of the bone marrow and it’s in a heterogeneous group of neoplasm arising from transformation of uncommitted or partial committed hematopoietic cells. This study was conducted at Khartoum state Sudan during October to December 2015. Aim: The aim of the study was to assess liver functions in leukemic patients. Methods: In this study (100) blood samples were tested, 50 samples for known patients with leukaemia and 50 samples from healthy persons as control group. Liver biochemical tests and enzymes were analyzed by auto-analyzer (BS-200 Chemistry Analyzer, Mindray). Results: The study demonstrated significant increasing of liver enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gammaglutamyltransferase(GGT) and globulins in leukemic patients, the mean levels were (54.32U/L), (43.10U/L), (116.10U/L, 33.4U/L,3.94g/dl ) respectively, p.value (0.000, 0.000, 0.000, 0.000, 0.006), respectively. Also this study demonstrated insignificant variation of total proteins, albumin and globulin. In addition the study showed that the liver enzymes AST, GGT and albumin were increased significantly p.value (0.000, 0.008, 0.037) in the female leukemic patients rather than in male leukemic patients when compared according to sex. Moreover, ALT and GGT were significantly increased in the age group less than 40 years and decreased in the age group more than 40 years when compared according to age, p.value (0.001, 0.003). There was statistical significance increased in liver enzymes AST, ALT, ALP, and GGT in acute leukaemia (AML and ALL), p.value was (0.000, 0.002, 0.000, 0.000), respectively, while the enzymes decreased in chronic leukaemia (CML and CLL), when compared according to type of leukaemia.