A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china

// Jin-Hu Fan 1, * , Yu-Qing Zhang 1, * , Su-Sheng Shi 2 , Yuan-Jia Chen 3 , Xing-Hua Yuan 4 , Li-Ming Jiang 5 , Shao-Ming Wang 1 , Li Ma 6 , Yu-Tong He 7 , Chang-Yan Feng 8 , Xi-Bin Sun 9 , Qing Liu 10 , Katrina Deloso 11 , Yihebali Chi 12 and You-Lin Qiao 1 1 Department of Cancer Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College 2 Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College 3 Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences 4 Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College 5 Department of Radiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College 6 Department of Epidemiology, Dalian Medical University 7 Hebei Cancer Registry, the Fourth hospital of Hebei medical university 8 Department of Nutrition, Chongqing Cancer Hospital & Institute & Cancer Center 9 Department of Cancer Epidemiology, Henan Cancer Hospital/Institute 10 Department of Cancer Prevention, Sun Yat-sen University Cancer Center 11 Division of Biological Sciences, the University of Chicago 12 Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College * These authors have contributed equally to this work Correspondence to: You-Lin Qiao, email: Qiaoy@cicams.ac.cn Yihebali Chi, email: yihebalichi@hotmail.com Keywords: neuroendocrine tumors, digestive system, epidemiology, retrospective study multicenter study Received: October 20, 2016     Accepted: April 11, 2017     Published: May 03, 2017 ABSTRACT Background: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. Methods: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients’ information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared. Results: The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger ( P <0.001), female ( P <0.001), urban ( P <0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage ( P <0.001) and lower grade ( P <0.001). Surgery remained the primary treatment method in all groups. Conclusions :More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes.