Evaluation of the efficacy of gonadotrophic inductors of ovulation in rats with hyperandrogenemia given flutamide

The objective of the present work was to study the influence of antiandrogen flutamide (flutapharm) at a dose of 1.0 mg/kg b.w., human chorionic gonadotropin (choragon, 5 IU), and folliculostimulating hormone (menopur, 0.01 IU) on the morphofunctional characteristics of ovaries. These products were administered either alone or sequentially to sexually mature female rats after the implantation of testosterone-containing polymeric capsules. The presence of hyperandogenism was confirmed by the five-fold rise in the blood testosterone levels. Analysis of the oestrus cycle, the weight and histological structure of the ovaries gave evidence of disturbed folliculogensis, degenerative changes in follicular epithelium, the development of ovarian polycystosis and anovulatory state in the hyperandrogenic animals. It is concluded neither flutamide nor gonadotrophic hormones administered at the above doses promoted normalization of the generative function of rat ovaries. At the same time, stimulation with gonadotropins following glutamide administration restored folliculogenesis, ovulation, an formation of luteal bodies. The results of this study indicate that flutamide can be used to enhance the stimulating action of gonadotropic hormones on the ovaries in hyperandrogenic individuals.