Antiplasmodial, analgesic and anti-inflammatory effects of crude Guiera senegalensis Gmel (Combretaceae) leaf extracts in mice infected with Plasmodium berghei

of 1100 mg/kg bw. Only the methanolic fraction had antiplasmodial effect while ethylacetate and hexane fractions were ineffective. Furthermore the methanolic extract produced a significant (p<0.05) suppression of up to 67.52% levels. The extracts had no prophylactic effect and high parasitaemia including mortality of sub-inoculated mice were obtained on day 14 post treatment. It gave 44.83% analgesic effect but was devoid of anti-inflammatory activity. Phytochemical screening indicated the presence of alkaloids, glycosides, tannins and flavonoids. Key words: