Measurement of embryo volume at 7-10 weeks' gestation by 3D-sonography.

SummaryThe embryo volume (EV) is an important parameter for the early diagnosis of growth disorders. The objective of this study was to establish normal data for EV at 7–10 weeks' gestation with three-dimensional ultrasonography (3DUS). A cross-sectional study involving 50 pregnancies was performed. An endocavitary volumetric transducer (3D5–8EK) was used for all measurements. The VOCAL (Virtual Organ Computer-aided AnaLysis) method with a 30° rotation angle was used for volumetric calculations. To analyse the correlation between EV and gestational age (GA) and crown–rump length (CRL), regression models were constructed. The mean, standard deviation, median, minimum and maximum values were calculated for each gestational age. The intraclass correlation coefficient (ICC) was used to determine inter- and intraobserver reliability. There was a significant correlation between EV and GA and CRL (R2 = 0.951 and R2 = 0.880, respectively). The exponential equation was the model that best expressed the correlation...