Study on the association of indoor air pollution with exhaled nitric oxide of asthma children

Background: Exposure to outdoor air pollutant can induce air way inflammation and exacerbation of asthma in children. However, there is limited knowledge about the effects of exposure to indoor air pollutants, such as formaldehyde, Volatile Organic Compounds, PM2.5 and nitrogen dioxide. Aims: The aim of this study was to investigate the association of exposure to indoor air pollution and nitric oxide in exhaled air (FeNO) as a biomarker of airway inflammation of asthma children. Methods: We conducted a population-based cross-sectional study of 60 asthma children aged 6-13 years in Beijing. Formaldehyde, volatile organic compounds (benzene, toluene, butyl acetate, styrene, ethyl benzene, xylenes, n-undecane), nitrogen dioxide and PM2.5 (during 1 week) in indoor air were assessed. FeNO, a marker of airway inflammation, was detected after indoor air pollutants sampling. We examined associations between the pollutants and FeNO using logistic regression models. Results: We observed significant relationship bet...