Evaluation of oral hypoglycemic potency of Medicago polymorpha and Zygophyllum simplex: A Drug – Drug interaction study

Objective: To identify a natural source of oral hypoglycemic agents outlining the herbal importance in modern day medicinal practice. Materials and Methods: ‘Medicago Polymorpha’ and ‘Zygophyllum Simplex’ were selected as crude drugs from which the extracts shall be prepared and tested in male albino mice to determine the oral hypoglycemic potency. Statistical Analysis used: Descriptive statistics were obtained through ANOVA and employed Unpaired t test as post-test, n=5 animals per group and results were expressed as Mean ± SEM, P* < 0.05 is considered as significant in the results Results: the chosen agents failed to produce the intended effect in mice which were prior treated with alloxan as diabetes inducing agent. Event their combination to study the drug – drug interaction also failed to impress through results. Discussion: neither individually nor in combination the drugs have got any marked medicinal importance. The in the future use of this medication may be justified less potent in the management of oral hypoglycemia through the natural agents. Conclusion: the study identified the drugs to be less potent in the management of laboratory induced hyperglycemia in mice. If at all these agents are preferred as additives in the management of the hyperglycemia, a thorough study must be carried out before the usage of the crude drugs a therapeutic agents.