Hypoglycemic and Hypolipidemic effect of Azadirachta indica seed oil and Mehani (Polyherbal Formulation) on Alloxan induced Diabetic Albino Rats

The present study aims to investigate the hypoglycaemic and hypolipidemic effect of Azadirachta indica seed oil and Mehani (Poly Herbal Formulation) in alloxan induced diabetic wistar albino rats. The rats were divided into 6 groups, each consisting of 6 rats: Control (Normal) rats, diabetic induced rats received alloxan (150/ Kg in 3 doses), diabetic induced rats treated with Azadirachta indica seed oil (5ml/Kg orally for 21 days), Normal rats treated with Azadirachta indica seed oil, Diabetic induced rats treated with Mehani (2gm/60Kg orally for 21 days) and Normal rats treated with Mehani. The rats were monitored for plasma glucose, glucose metabolising enzymes hexokinase and glucose-6-phosphatase and Lipid profile. Alloxan induced diabetic rats shows a high blood glucose with altered lipid profile and altered level of glucose metabolising enzymes which was counteracted upon treatment with Azadirachta indica seed oil and Mehani which shows significant (p<0.01) reduction in blood glucose, serum cholesterol, serum triglyceride and glucose-6-phosphatase level and significant (p<0.01) increase in the level of hexokinase and serum HDL suggesting its hypoglycaemic and hypolipidemic role. Again in comparison to Azadirachta indica seed oil, Mehani (Poly Herbal Formulation) have more hypoglycaemic and hypolipidemic effect.