The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α.

Ting Han,Maria Goralski,Emanuela Capota,Shae B. Padrick,Jiwoong Kim,Yang Xie,Deepak Nijhawan

The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α.

2016

Ting Han
Maria Goralski
Emanuela Capota
Shae B. Padrick
Jiwoong Kim
Yang Xie
Deepak Nijhawan

A forward-genetic screen revealed that the mutations in DNA polymerase α (POLA1) are resistant to the effects of CD437. The direct interaction of CD437 and POLA1 blocks DNA replication and promotes cancer cell death.

Keywords:

Biochemistry
Cancer cell
DNA replication
Molecular biology
DNA polymerase
Biology
Toxin
DNA repair
DNA polymerase II
DNA polymerase I
DNA polymerase delta
S phase
DNA synthesis

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