The role low microRNA-335 expression in prognosis prediction of human cancers.

Introduction: MicroRNA-335 (miR-335) serves as one of the known miRs in human cancers, however, its prognostic role has yet been settled down. The present research is formed to discuss whether or not miR-335 could be identified as a prognostic biomarker of human cancers. Materials and Methods: All eligible references from four main databases were included in this study based on the inclusion/exclusion criteria. Moreover, we performed a meta-analysis to explore the prognostic role of miR-335 in human cancers. Results: Finally, we found eight articles which met the inclusion/exclusion criteria, involving 1098 subjects. miR-335 is deregulated in human cancer tissues compared to noncancerous tissues. We found that the pooled hazard ratios with 95% confidence interval were 1.35 (1.00, 1.83) for overall survival and 1.54 (0.36, 6.68) for relapse-free survival. Conclusion: The prognostic value of the low miR-335 expression cannot be completely decided based on the present evidences. More related clinical research should be implemented to further study the prognostic role of miR-335 in human cancers.