(Oxazolidinon-5-yl-methyl) -2-thiophen-carboxamides and their use in the field of blood coagulation

2008 
Compound of the formula wherein R1 is chlorine, trifluoromethoxy, methyl, ethyl, n-propyl, methoxy, methoxymethyl or ethoxymethyl, R2 is hydrogen or methyl, and R3 represents a group of formula in which * is the point of attachment to oxopyridine ring, n represents the number 1, 2, 3 or 4, m represents the number 1 or 2, R4 represents hydrogen, methyl, ethyl, cyclopropyl, cyclobutyl, 2-hydroxyeth-1-yl-3-hydroxyprop-1- yl 3-yl methoxyprop-1-yl 4-hydroxycyclohex-1-, 2-methoxyeth yl-1-,,, tetrahydrofuran-2-ylmethyl or 1,4-dioxan-2-ylmethyl, R 5 represents hydrogen, methyl or ethyl, or R4 and R5 together with the nitrogen atom to which they are attached form a pyrrolidin-1-yl, 2-ring methoxymethylpyrrolidin-1-yl, morpholin-ring 4-yl ring, a 1,1 -dioxotiomorfolin-4-yl, 1,4-ring oxazepan-4-yl, 4-methylpiperazin-1-yl ring or a 4-hydroxypiperidin-1-yl, R6 represents hydrogen, methyl, ethyl, cyclopropyl, cyclobutyl, 2-hydroxyeth-1-i 2-methoxyeth yl what-1-yl 4-hydroxycyclohex-1-, 3-hydroxyprop yl-1, 3-methoxyprop-1-yl, tetrahydrofuran-2-ylmethyl or 1,4-dioxan-2-ylmethyl, R7 represents hydrogen, methyl or ethyl, or R6 and R7 form with the nitrogen atom to which they are attached a ring pyrrolidin-1-yl ring, a 2-methoxymethylpyrrolidin-1-yl ring, a morpholin-4-yl ring, a 1,1-dioxothiomorpholin-4-yl, 1,4-ring oxazepan-4-yl, 4-methylpiperazin-1-yl ring or a 4-hydroxypiperidin-yl-1, or a their salts, solvates or the solvates of its salts
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