Therapeutic effect of epinephrine combined with vasopressin on cardiopulmonary resuscitation

Objective:To evaluate the effects of vasopressin combined with epinephrine on the dog model of duration ventricular fibrillation during cardiopulmonary resuscitation(CPR).Method:After modelled ventricular fibrillation and given basic life support cardiopulmonary resuscitation(BLS-CPR) for 3 min,28 healthy mongrel dogs were randomly assigned to 4 groups and provided with drugs intravenously every 3 min.Group A received only epinephrine(45 μg/kg,n=7),group B1 was treated with epinephrine(45 μg/kg) combined with vasopressin(0.4 U/kg),group B2 was treated with epinephrine(45 μg/kg) combined with vasopressin(0.8 U/kg),and group B3 was treated with epinephrine(45 μg/kg) combined with vasopressin(2.4 U/kg).The terminal point is the return of spontaneous circulation,cardiac arrest,or continuous ventricular fibrillation.Result:Only two animals(28.6%) in group A had return of spontaneous circulation,and six(85.7%) in group B1 after the execution of BLS-CPR and electric defribrillation,both B2 and B3 achieved 100%.The time of the return of spontaneous circulation was(74.9±6.52)s in group B1,(71.6±4.89)s in group B2,(70.4±5.66)s in group B3 respectively,all shorter than that of group A(all P0.01).Conclusion:During CPR in ventricular fibrillation,administration of vasopressin combined with epinephrine results in significant increases in CPP,and the best dosage of vasopressin is 0.8 U/kg.