Green Synthesis and in silico Neuraminidase Study of Some Substituted 2-Benzylidene-1-Benzofuran-3-Ones

An improved and green method has been developed for the synthesis of substituted 2-benzylidene-1-benzofuran-3-ones by treating 2-hydroxychalcones with CuBr 2 in DMF-water mixture (7:3; v/v) using grinding methodology. Molecular docking study was also carried out and it revealed that compound 4h binds with the active amino Glu-277, Try-406 and Arg-152 of neuraminindase against influenza virus.