A family of metal-dependent phosphatases implicated in metabolite damage-control

Lili Huang,Anna N. Khusnutdinova,B. Nocek,Greg Brown,Xiaohui Xu,Hong Cui,Pierre Petit,Robert Flick,Rémi Zallot,Kelly Balmant,Michael J. Ziemak,John Shanklin,Valérie de Crécy-Lagard,Oliver Fiehn,Jesse F. Gregory,Andrzej Joachimiak,Alexei Savchenko,Alexander F. Yakunin,Andrew D. Hanson

A family of metal-dependent phosphatases implicated in metabolite damage-control

2016

Lili Huang
Anna N. Khusnutdinova
B. Nocek
Greg Brown
Xiaohui Xu
Hong Cui
Pierre Petit
Robert Flick
Rémi Zallot
Kelly Balmant
Michael J. Ziemak
John Shanklin
Valérie de Crécy-Lagard
Oliver Fiehn
Jesse F. Gregory
Andrzej Joachimiak
Alexei Savchenko
Alexander F. Yakunin
Andrew D. Hanson

Characterization of three DUF89 subfamilies representing all domains of life reveals that members function as metal-dependent phosphatases that help eliminate a wide range of damaged phosphometabolites.

Keywords:

Enzyme
Biochemistry
Metabolism
Metabolite
Phosphatase
Biology
Transferase

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