Quimioterapia pre-operatoria y nutrición parenteral total en la neoplasia de colon

Aim: The objetive of this study was to determine the effect of TPN after surgery in patients with colon carcinoma and preoperative chemotherapy. Material and method: The study included 27 patients, 16 men and 11 women, with a mean age of 62.1 ± 11.2 years. The patients were divided into two groups according to whether they had undergone chemotherapy (Group A; n = 11) or not (Group B, control; n = 16) prior to surgery. Almost two thirds of the patients were in stage III of the disease. Among those receiving this treatment, 60% were given 5-fluorouracil plus leucovorin at a dose of 5.5 ± 2.7 cycles/patient and the others received different regimens. TPN was established early with a mean of 11.7 ± 9.2 days. The clinical and nutritional assessment was performed before surgery and at the end of TPN administration. Results: The mean body mass index (BMI) was 24.1 ± 2.2 kg/m 2 . Comparison between the groups before the start of TPN showed statistically significant differences in red blood cell and platelet counts (P = .013 and P = .02, respectively). These differences had disappeared at completion of TPN, suggesting that this treatment can reverse the hematological changes induced by chemotherapy. Conclusion: In patients who receive chemotherapy before surgery and in whom TPN it was indicated the combination of these two treatments could be beneficial. (Nutr Hosp. 2006;21:303-306)