Synthesis, antimycobacterial and antibacterial activity of 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety

Abstract A series of novel 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety were synthesized and evaluated for their biological activity. Our results reveal that compounds 9a – 9c have considerable activity against both of MTB H37Rv ATCC 27294 (MICs: 3.81–7.13 μg/mL) and methicillin-sensitive Staphylococcus aureus strains (MICs: