Microwave-assisted synthesis of carboxanilides as non steroidal anti- inflammatory agents

A series of 3-hydroxybenzofuran-2-carboxanilides were prepared by microwave irradiation and conventional heating method. Microwave irradiation method gives better yield as that of conventional heating with a shorter reaction time. Compounds were characterized by physical data, elemental analysis and spectral data. All the new compounds were screened for anti-inflammatory activity by carrageenan induced rat paw edema method by using diclofenac sodium as a standard. Compounds 2c, 2e and 2f showed very good anti-inflammatory activity.