Meditation and mindfulness reduce perceived stress in women with recurrent pregnancy loss: A randomized controlled trial with a 12-month follow-up

Abstract Research question Can participating in a tailored 7-week meditation and mindfulness program with additional standard supportive care versus only standard supportive care reduce perceived stress for women with recurrent pregnancy loss? Design A two-armed randomized controlled trial with 12-month follow-up. In total 76 patients were enrolled and randomly assigned to either standard supportive care or to a 7-week meditation and mindfulness program led by an instructor in addition to standard supportive care. Results At intervention completion (7 weeks after) perceived stress decreased significantly both in the intervention group; p =  Conclusion This first RCT of a tailored meditation and mindfulness intervention for women with RPL document that a 7-week daily at-home meditation and mindfulness program combined with group sessions reduced perceived stress significantly more than our standard supportive care program. Future studies should address the most effective format and the “dose” needed for an impact on perceived stress levels. The trial is registrated on Clinicaltrial.gov as NCT03905395.