Seeing the Forest for the Trees: Kidney Oncogenomes in Relation to Therapeutic Outcomes

Renal cell carcinoma is a heterogeneous disease, and tissue investigations provide clues that may predict treatment response. Oncogenomic analysis of five outliers, who achieved a sustained response with rapalogs, implicates alterations of the TSC1 and mTOR genes and reveals insights into the conserved evolution of tumors. Clin Cancer Res; 20(7); 1721–3. ©2014 AACR .