New method for purifying elubiol
2012
The invention discloses a new method for purifying elubiol. 2-methyl-2-pentanone which is used in present elubiol recrystallization has a high price, is not economic, and is detrimental to the human health because ketone chemicals are residual in products. The method of the invention comprises the following steps: 1, dissolving crude elubiol with a mixed solution of water and a low chain alkyl alcohol at 50-85DEG C; and 2, decoloring by adding active carbon to the elubiol-dissolved mixed solution, filtering to remove carbon, crystallizing by cooling to a certain temperature, filtering again, and drying. According to obtained fine elubiol, the content is above 99.0%, the HPLC purity is above 99.5%, and the melting point is between 127.6DEG C and 130DEG C. The method of the invention has the advantages of conciseness, low cost, good stability of the purified elubiol, and total molar yield of the reaction of 89-91%.
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