Inhibition of cholesterol side-chain cleavage by intermediates of an alternative steroid biosynthetic pathway
1988
Abstract Mitochondrial preparations from endocrine tissues were incubated with radioactive cholesterol and the effect of hydroxylated metabolites of 23,24-dinor-5-cholen-3β-ol (23,24-dinor-5-cholene-3β,20-diol and 23,24-dinor-5-cholene-3β,21-diol) on the production of pregnenolone was measured. These compounds are intermediates in an alternative, sesterterpene pathway for steroid hormone biosynthesis. It was found that these materials, like the analogous side-chain-hydroxylated derivatives of cholesterol (20α-hydroxycholesterol and 22 S -hydroxycholesterol), inhibit cholesterol side-chain cleavage. The possibility that there could be a control mechanism whereby metabolites of 23,24-dinor-5-cholen-3β-ol inhibit steroidogenesis occurring by the cholesterol pathway is discussed.
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