The K121Q polymorphism of the PC-1 gene is not associated with abnormal glucose tolerance or cardiovascular risk factors in women with previous gestational diabetes mellitus El polimorfismo K121Q del gen PC-1 no está asociado con alteración del metabolismo de la glucosa ni riesgo cardiovascular en mujeres con diabetes mellitus gestacional previa

Introduction: Women suffering gestational diabetes mellitus (GDM) are a risk group for diabetes at long-term. Insulin resistance is related to environmental and genetic factors. Controversial data exists about association between K121Q PC-1 gene polymorphism and diabetes, obesity and/or insulin resis- tance. The aim of the study was to investigate the relationship between K121Q PC-1 gene polymorphism and the glucose metabolic alterations or metabolic syndrome variables. Patients and methods: 97 women with previous GDM were reclassified by means of oral glucose tolerance test in the early postpar- tum. Anthropometric, biochemical and K121Q genotypes frequencies were studied. Results: 61% of the patients had normal glucose tolerance, 29% met diagnostic criteria of prediabetes, and 10% diabetes mellitus. No signifi- cant differences in the 121Q allele have been found between women with and without glucose intolerance, diabetes or metabolic parameters associated with metabolic syndrome. Conclusion: Although further poblational studies are necessary, in this study, the K121Q PC-1 gene polymorphism is not associ- ated with type 2 diabetes, glucose intolerance or cardiovascular risk factors in women with previous GDM.