Toward the clinical application of time-domain fluorescence lifetime imaging

High-speed video-rate fluorescence lifetime imaging FLIM through a flexible endoscope is reported based on gated opti- cal image intensifier technology. The optimization and potential ap- plication of FLIM to tissue autofluorescence for clinical applications are discussed. © 2005 Society of Photo-Optical Instrumentation Engineers. DOI: 10.1117/1.2102807