Synthesis and anti-platelet aggregating activity of 3-hetero analogues of (+)-9(O)-methano-delta 6(9 alpha)-prostaglandin I1.

Optically active 3-hetero analogues of isocarbacyclin (34a, 38, 39, 40 and 42) as well as ω-chain analogues have been synthesized from the bicyclic alcohol (1). Compound 34d had more potent anti-platelet aggregating activity than prostacyclin in human platelet-rich plasma.