The effect of biofeedback combined with drugs therapy on interferon-γ and transforming growth factor-β1 in expressed prostatic secretions of patients with chronic prostatitis / chronic pelvic pain syndrome

Objective To study the effect of biofeedback combined with drugs therapy on interferon-γ(INF)-γ and transforming growth factor-β1(TGF-β1)in expressed prostatic secretions of patients with chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS).Methods Fifty-five patients who had been diagnosed as CP/CPPS were classified according to U.S.National Institutes of Health(NIH)classification system for prostatitis and received the treatment of biofeedback therapy (20 times and 20 min every time)in addition to the general drugs.The efficacy was evaluated by the NIH chronic prostatitis symptom index(NIH-CPSI)before and after treatment.INF-γ and TGF-β1 levels were measured in expressed prostatic secretions of 55 patients with CP/CPPS and 16 normal controls by double antibody enzyme-linked immune sandwich assay.Results The overall NIH-CPSI scores were(26.36 ± 6.16)scores and(10.24 ± 5.18)scores,and symptom degree scores were(19.59 ± 4.67)scores and (7.35 ± 3.46)scores pre-and post-treatment in 55 patients with CP/CPPS,significant differences of reduces were found compared with pre-treatment(P ＜ 0.01).INF-γ and TGF-β 1 levels in expressed prostatic secretions pre-treatment in CP/CPPS patients with Ⅲ A type and Ⅲ B type were higher than those in normal controls [(14.89 ± 7.43),(13.51 ± 5.88)ng/L vs.(7.56 ± 1.52)ng/L,(8464.41 ± 4604.49),(7985.19 ± 5068.07)ng/L vs.(2475.50 ± 973.42)ng/L],there were significant differences(P ＜ 0.01);which post-treatment were lower than those pre-treatment [(8.63 ± 1.86),(8.23 ± 1.75)ng/L and(2887.32 ±926.45),(2576.50 ± 955.38)ng/L],and there were significant differences(P ＜ 0.01),but there was no significant difference compared with normal controls(P ＞ 0.05).Conclusion Biofeedback combined with drugs therapy in treatment of CP/CPPS is effective and safe.And the expression of INF-γ and TGF-β1 in expressed prostatic secretions can be significantly reduced by this therapy. Key words: Biofeedback, psychology; Prostatitis; Interferon-gamma; Transforming growth factor beta1