Effect and Regulation of Connective Tissue Growth Factor on Peritoneal Fibrosis

Peritoneal fibrosis has gradually become the main reason for the withdrawal of maintenance peritoneal dialysis patients.Peritoneal fibrosis is a complicated process controlled by various factors.Connective tissue growth factor (CTGF),a common downstream mediator of the promoting fibrosis stimulators,has played important effect in this pathophysiological process.Moreover,CTGF is considered to be a better target to prevent peritoneal fibrosis.In this paper,the mechanism of peritoneal fibrosis caused by non-physiologic peritoneal dialysis solutions,the biological characteristics of CTGF,and the effect and regulation of CTGF in the process of peritoneal fibrosis are reviewed.