308 Temporal bone pneumatization in adult patients with cystic fibrosis

Objectives: Long term survival after lung transplantation has significantly improved during the last 10 years. On the other hand, complications have increased. Renal diseases, most probably related to the immunosuppression therapy and cystic fibrosis therapy such as antibiotic threrapy, are important complications during the followup. Methods: During the period November 1996 up to now 84 lung transplantation recipients with with cystic fibrosis (40 males) followed in our center according to a pre-established follow-up protocol for Tx patients: During the follow-up period all patients developed renal complications. The mean time of occurrence after lung transplantation was 12 months. All patients have reduced immunosuppression therapy during the follow-up period (in 10 patient Tacrolimus was changed to Rapamycin) Three patients (2 females) developed severe renal complications after 8, 10, 13 years after lung transplantation, and underwent kidney transplantation. Two pts are alive after 4 and 1 year after renal transplantation with good pulmonary function (FEV1 65% and 85% predicted) normal creatinine serum level and good creatinine clereance. One pt (female) died after 1 year after renal transplantation due to bronchiolitis obliterans syndrome. Conclusion: Renal diseases after lung transplantation are an important complication; A multidisciplinary approach is needed since the beginning of the followup, in order to obtain precocious diagnosis and establish an adequate therapy. Kidney transplantation for our opinion is a good opportunity in pts with severe renal complication. 308 Temporal bone pneumatization in adult patients with cystic fibrosis M.C. Berkhout1, C.J. van Rooden2, R.C. Aalbers3, E. Rijntjes3, L.H. el Bouazzaoui1, H.G.M. Heijerman1. 1Haga Teaching Hospital, Pulmonary Diseases, The Hague, Netherlands; 2Haga Teaching Hospital, Radiology, The Hague, Netherlands; 3Haga Teaching Hospital, Otorhinolaryngology, The Hague, Netherlands