As bile acid sequestrants poly imidazole

The present invention provides a polymer for binding bile salts and removing the amine crosslinked effective from the gastrointestinal tract. The bile acid binder may be a polymer or a pharmaceutical composition administered to a subject to treat various conditions, including hypercholesterolemia, diabetes, pruritus, irritable bowel syndrome - diarrhea (IBS-D), a bile acid absorption and poor.