2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors for the treatment of HCV
2014
Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβleads to potent inhibition of HCV replication as observed in genotype (GT) 1a and 1b replicon and GT2a JFH1 virus assays in vitro.
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