血友病及びその類縁疾患患者におけるC型肝炎ウイルス (HCV) 抗体の検出

The prevalence of antibodies to hepatitis C virus (HCV) was investigated using HCV Ab ELASA kit (Ortho diagnostics) on a total of 167 Japanese patients with hemophilia and its related disorders. Seropositive reaction was found in 82 out of 126 (65%) patients with hemophilia A, 10 out of 17 (59%) patients with hemophilia B, 8 out of 17 (47%) patients with von Willbrand disease, and one out of 7 (14%) patients with congenital platelet function disorders. The patients having positive HCV Ab reaction received clotting factor concentrates on a total amount of 37, 570 units annually, whereas those with the negative 23, 689 units. The higher percentage of seropositive reaction was observed in the patients aged from 10 to 50 years old. The five hemophilias showed seronegative conversion on their clinical course over 5 years, and one had transient seropositive conversion.