Current efficacy of postexposure prophylaxis against measles with immunoglobulin

Abstract We assessed results after postexposure prophylaxis against measles with immunoglobulin administered intramuscularly. Children were given 0.33 mL/kg of immunoglobulin from commercially available lots containing various titers of measles antibody within 5 days after exposure. In children receiving immunoglobulin with a titer of ≤16 IU/mL, 57% had clinically evident measles. Immunoglobulin preparations with higher measles antibody titers are required. (J Pediatr 2001;138:926-8)